Nano Copper in Poultry Nutrition: Potential Effect and Future Prospect - A Review

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  • N.AminullaAfghanistan National Agricultural Sciences and Technology University, Kandahar 0093, Afghanistan
  • T.M.PrabhuVeterinary College, Hebbal, Bengaluru
  • B. N.SureshVeterinary College, Hebbal, Bangalore
  • A. Mostamand


Bioavailability, Copper, Nanoparticles, Poultry


Copper (Cu) is an essential trace element and plays a key role in maintenance, production and health of birds. Hence, supplementation of Cu has become a common practice in poultry diets. However, the bioavailability of Cu from feed ingredients as well as from its inorganic salts is low. This results in Cu deficiency in the body or may lead to excess excretion and environmental toxicity if supplemented at higher levels. Thus, strategies to improve bioavailability of Cu from its conventional sources for use in poultry diets assume significance. In this context, nano-technology has been demonstrated to be beneficial in various biological fields including poultry nutrition. Nano Cu (NCu) has additional novel properties (size, shape, concentration, surface charge and reactivity) compared to its conventional inorganic form. The improved nutrients utilization and growth performance of birds was observed upon dietary inclusion of NCu. This effect was attributed to better gut health due to antimicrobial properties of NCu and also due to its positive effect on growth hormone axis, expression of hypothalamic appetite regulating genes and dietary energy and fat utilization. In various studies, the metabolizability of nutrients and growth performance of birds was improved or remained comparable at reduced supplementation level of NCu in the diets. Further, reduced Cu interaction with phytic acid, iron and zinc forming an insoluble complex was observed when NCu used in the diets. Increased Cu deposition in the tissues and reduced Cu excretion due to NCu inclusion in the poultry diets were also observed. However, suppressed immune response and antioxidant status was reported due to relatively higher dose of dietary NCu in chicken. This may be due to inappropriate stimulation of immune system or over production of reactive oxygen species due to nanoparticles in the body. Due to numerous advantages, the application of NCu in poultry nutrition is continue to develop and further studies are required to fulfil the knowledge gap in physicochemical characteristics of nanoparticles and their potential effect on various parameters in poultry.


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Abd El-Ghany, W.A., Shaalan, M. and Salem, H.M. 2021. Nanoparticles applications in poultry production: an updated review. World's Poultry Science Journal. 77(4): 1001-1025.

Al-Bairuty, G. A., Boyle, D., Henry, T. B., Handy, Sublethal, R.D. 2016. Effects of copper sulphate compared to copper nanoparticles in rainbow trout (Oncorhynchus) at low pH: physiology and metal accumulation. Aquatic Toxicology. 177: 188–198.

Alber, F., Dokudovskaya, S., Veenhof, L.M., Chait, B.T., Sali, A. and Rout, M.P. 2007. The molecular architecture of the nuclear pore complex. Nature. 450(2): 695–701.

Aminullah, N., Prabhu, T. M., Naik, J., Suresh, B.N. and Indresh, H.C. 2021. Performance of Swarnadhara breeder hens supplemented with reduced levels of different copper forms. Veterinary World. 14(5): 1371-1379.

Aminullah, N., Prabhu, T.M., Naik, J., Suresh, B. N. and Suma. N. 2022. Effect of reduced dietary copper levels sourced from organic and nanoparticles forms on performance and nutrient utilization in Giriraja Birds. Indian Journal of Animal Research. 56(1): 58-6.

Aminullah. 2022. Effect of dietary organic and nano copper on growth performance, meat and egg quality traits in Giriraja and Swarnadhara chicken. Doctoral Dissertation, Karnataka Veterinary Animal and Fisheries Sciences University, Bidar, Karnataka, India.

Anjum, N. A., Rodrigo, M. A. M., Moulik, A., Heger, Z., Kopel, P., Zitka, O., Lukatin, A. S., Duarte, A. C., Pereira, E. and Kizek, R. 2016. Transport phenomena of nanoparticles in plants and animals/ humans. Environmental Research. 151:233–243.

Aoyagi, S. and Baker, D.H. 1993. Estimates of copper bioavailability from liver of different animal species and from feed ingredients derived from plants and animals. Poultry Science. 72(9): 1746-1755.

Arredondo, M. and Nunez, M.T. 2005. Iron and copper metabolism. Molecular Aspects of Medicine. 26(4-5): 313-327.

Baker, D.H., Odle, J., Funk, M.A. and Wieland, T.M. 1991. Bioavailability of copper in cupric oxide, cuprous oxide and in a copper-lysine complex. Poultry Science.70: 177-179.

Balakrishnan, V. 2010. Hand Book on TANUVAS SMART Mineral Mixture. Tamil Nadu Veterinary and Animal Sciences University, Chennai-51.

巴雷特,k . E Boitano,年代,招待,S m和兄弟oks, H. L. 2010. Ganong’s Review of Medical Physiology. 23rd Edition. The McGraw-Hill Companies.

Basuini, M.F., El-Hais, A. M., Dawood, M.A.O., Abou-Zeid, A.E., El-Damrawy, S. Z., Khalafalla, M. M. E-S., Koshio, S., Ishikawa, M. and Dossou, S. 2016. Effect of different levels of dietary copper nanoparticles and copper sulfate on growth performance, blood biochemical profiles, antioxidant status and immune response of red sea bream (Pagrus major). Aquaculture. 455: 32–40.

Camacho-Flores, B.A, Martinez-Alvarez, O., Arenas-Arrocena, M.C., Garcia-Contreras, R., Argueta-Figueroa, L., De La Fuente-Hernández, J. and Acosta-Torres, L.S. 2015. Copper: synthesis techniques in nano scale and powerful application as an antimicrobial agent. Journal of Nanomaterials. p 1–10.

Carter, S.D. and Kim, H. 2013. Technologies to reduce environmental impact of animal wastes associated with feeding for maximum productivity. Animal Frontiers. 3(3): 42-47.

Civardi、C。舒伯特、M。Fey, A。,灯芯,p和Schwarze, F.W. 2015. Micronized copper wood preservatives: efficacy of ion, nano, and bulk copper against the brown rot fungus Rhodonia placenta. PloS One. 10(11):e0142578. Doi: 10.1371/journal.pone.0142578.

Collins, J. F., Prohask, J. R. and Knutson, M. D. 2010. Metabolic cross roads of iron and copper. Nutrition Review. 68(3):133–147.

Coppenet, M., Golven, J., Simon, J. C., Le Corre, L. and Le Roy, M. 1993. Chemical evolution of soils in intensive animal-rearing farms: the example of Finistere. Agronomie. 13(2): 77-83.

Di Giancamillo, A., Rossi, R., Martino, P. A., Aidos, L., Maghin, F., Domeneghini, C. and Corino, C. 2018. Copper sulphate forms in piglet diets: Microbiota, intestinal morphology and enteric nervous system glial cells. Animal Science Journal. 89(3): 616–624.

Din, M.I. and Rehan, R. 2017. Synthesis, characterization, and applications of copper nanoparticles. Analytical Letters. 50:50–62.

Dozier, W.A., Davisa, J., Freeman, M.E. and Ward, T.L. 2003. Early growth and environmental implications of dietary zinc and copper concentrations and sources of broiler chicks. British Poultry Science Journal. 44(5): 726–731.

EFSA. 2016. Revision of the currently authorized maximum copper content in complete feed. EFSA Journal. 14:4563.

Elder, A., Vidyasagar, S. and Delouise, L. 2009. Physicochemical factors that affect metal and metal oxide nanoparticles passage across epithelial barriers. Wiley Interdiscip. Review Nanomed. Nano-biotechnology. 1: 434–450.

El-Kazaz, S. E., Angel, C. and Hafez, M. H. 2020. Evaluation of copper nanoparticles and copper sulfate effect on immune status, behaviour, and productive performance of broilers. Journal of Advanced Veterinary and Animal Research. 7(1): 16-25.

埃斯皮诺萨,C.D.和斯坦,2021年第三世。消化率and metabolism of copper in diets for pigs and influence of dietary copper on growth performance, intestinal health, and overall immune status: a review. Journal of Animal Science and Biotechnology. 12(1): 1-12.

Feng, M., Wang, Z. S., Zhou, A. G. and Ai, D.W. 2009. The effects of different sizes of nanometer zinc oxide on the proliferation and cell integrity of mice duodenum- epithelial cells in primary culture. Pakistan Journal of Nutrition. 8(8): 1164–1166.

Ferket, P., Van, H. E. and Angel, R. 2002. Nutritional strategies to reduce environmental emissions from nonruminants. Journal of Animal Science. 80(E-suppl_2):168–182.

Gaetke, L.M. and Chow, C.K. 2003. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology. 189(1):147–163.

Gangadoo, S., Stanley, D., Hughes, R.J., Moore, R.J. and Chapman, J. 2016. Nanoparticles in feed: Progress and prospects in poultry research. Trends in Food Science and Technology. 58:115–126.

Gonzales, E. A., Fu C-M, L.U. F-Y. and Lien, T.F. 2009. Effects of nano-copper on copper availability and nutrients digestibility, growth performance and serum traits of piglets. Livestock Science. 126(1-3): 122–129.

Hagan, D.T. 1996. The intestinal uptake of particles and the implications for drug and antigen delivery. Journal of Anatomy. 189(3): 477–482.

Hefnawy, A. E. and El-Khaiat, H. 2015. Copper and animal health (importance, maternal fetal, immunity and DNA relationship, deficiency and toxicity). International Journal of Agronomy, Veterinary and Medical Sciences. 9(5): 195-21.

Hill, E.G., Johnson, S.B., Lawson, L.D., Mahfouz, M.M. and Holman, R.T. 2000. Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. In Proc.of the National Academy Science. 79(4): 953-957.

Hillyer, J.F. and Albrecht, R.M. 2001. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. Journal of Pharmacological Science. 90(12): 1927-1936.

Hoet, P.H., Bruske-Hohlfeld, I. and Salata, O.V. 2004. Nanoparticles – known and unknown health risks. Journal of Nano-biotechnology. 2(1):12.

Hoshino, A., Fujioka, K. and Oku, T. 2004. Physicochemical properties and cellular toxicity of nano crystal quantum dots depend on their surface modification. Nano Letters. 4(11): 2163–2169.

Jackelen, A.M.L., Jungbauer, M. and Glavee, G.N. 1999. Nano scale materials synthesis. 1. Solvent effects on hydridoborate reduction of copper ions. Langmuir. 15(7): 2322–2326.

Kawanishi, S., Inoue, S. and Yamamoto, K. 1989. Hydroxyl radical and singlet oxygen production and DNA damage induced by carcinogenic metal compounds and hydrogen peroxide. Biological Trace Elements and Research. 21(1):367–372.

Kegley, E.B. and Spears, J.W. 1994. Bioavailability of feed-grade copper sources (oxide, sulfate, or lysine) in growing cattle. Journal of Animal Science. 72(10): 2728-34.

Kim, J.W., Kim, J.H., Shin, J.E. and Kil, D.Y. 2016. Relative bioavailability of copper in tribasic copper chloride to copper in copper sulfate for laying hens based on egg yolk and feather copper concentrations. Poultry Science. 95(7): 1591–1597.

Kozlowski, K., Jankowski, J., Otowski, K., Zdunczyk, Z. and Ognik, K. 2018. Metabolic parameters in young turkeys fed diets with different inclusion levels of copper nanoparticles. Polish Journal of Veterinary Science. 2(21): 245–253.

Ledoux, D.R., Henry, P., Ammerman, C., Rao, P. and Miles, R. 1991. Estimation of the relative bioavailability of inorganic copper sources for chicks using tissue uptake of copper. Journal of Animal Science. 69(1):215–222.

Lee, D.Y., Schroder, J. and Gordon, P.T. 1988. Enhancement of the bioavailability of copper in the rat by phytic acid. Journal of Nutrition. 118: 712–716.

Lee, I. C., Ko, J. W., Park, S. H., Lim, J. O., Shin, I. S., Moon, C., Kim, S. H., Heo, J. D. and Kim, J. C. 2016. Comparative toxicity and bio distribution of copper nanoparticles and cupric ions in rats. International Journal of Nanomedicine. 11: 2883.

Leeson S. 2009. Copper metabolism and dietary needs. World’s Poultry Science Journal. 65: 353–365.

Lim, H. S. and Paik, I. K. 2006. Effects of dietary supplementation of copper chelates in the form of methionine, chitosan and yeast in laying hens. Asian-Australasian Journal of Animal Science. 19(8): 1174-1178.

Luo, X.G., Ji, F., Lin, Y.X., Steward, F.A., Lu, L., Liu, B. and Yu, S.X. 2005. Effects of dietary supplementation with copper sulfate or tribasic copper chloride on broiler performance, relative copper bioavailability and oxidation stability of vitamin E in feed. Poultry Science. 84(6): 888–893.

Luo, Y.H., Chang, L.W. and Lin, P. 2015. Metal-based nanoparticles and the immune system: activation, inflammation, and potential applications. BioMed Research International.:143720.

Luo.X, G. and Dove, C.R. 1996. Effect of dietary copper and fat on nutrition utilization, digestive enzyme activities, and tissue mineral levels in weanling pigs. Journal of Animal Science. 74(8):1888–1896.

Lyons, T.P. and Jacques, K.A. 1998. Biotechnology in the feed industry. In Proc. of Alltech's 14th Annual Symposium: Passport to the year 2000.

Maenz, D. D., Engele-Schaan, C.M. R., Ewkirkw, N. and Classen, H. L. 1999.The effect of minerals and mineral chelators on the formation of phytase-resistant and phytase susceptible forms of phytic acid in solution and in a slurry of canola meal. Animal Feed Science and Technology. 81(3-4):177–192.

Makarski, B. and Zadura, A. 2006. Influence of copper and lysine chelate on hematological and biochemical component levels in turkey blood. Annals Universities Marie Curie Sklodowska (section EE) 48: 357-363.

Mantovani, A. 2010. Molecular pathways linking inflammation and cancer. Current Molecular Medecine. 10:369–373

Michalak, I., Dziergowska, K., Alagawany, M., Farag, M.R., El-Shall, N.A., Tuli, H.S., Emran, T.B. and Dhama, K. 2022. The effect of metal-containing nanoparticles on the health, performance and production of livestock animals and poultry. Veterinary Quarterly: In press.

Morsy, E.A., Hussien, A.M., Ibrahim, M.A., Farroh, K.Y. and Hassanen, E.I. 2021. Cytotoxicity and genotoxicity of copper oxide nanoparticles in chickens. Biological Trace Element Research. 199(12): 4731-4745.

Mroczek, S. N., Lukasiewicz, M., Adamek, D., Kamaszewski, M., Niemiec, J., Wnuk-Gnich, A., Scott, A., Chwalibog, A. and Sawosz, E. 2017. Effect of copper nanoparticles administered in ovo on the activity of proliferating cells and on the resistance of femoral bones in broiler chickens. Achieves of Animal Nutrition. 71(4): .327-332.

Mroczek, S. N., Lukasiewicz, M., Wnuk, A., Sawosz, E., Niemiec, J., Skot, A., Jaworski, S. and Chwalibog, A. 2015. In ovo administration of copper nanoparticles and copper sulfate positively influences chicken performance: effect of Cu on chicken performance. Journal of Science and Food Agriculture. 96(9): 3058-3062.

Myers, S.A., Nield, A. and Myers, M. 2012. Zinc transporters, mechanisms of action and therapeutic utility: implications for Type 2 diabetes mellitus. Journal of Nutrition and Metabolism, doi:10.1155/2012/173712.

Najafi-Hajivar, S., Zakeri-Milani, P., Mohammadi, H., Niazi, M., Soleymani-Goloujeh, M. and Baradaran, B. 2016. Overview on experimental models of interactions between nanoparticles and the immune system. Biomed Pharmacother. 83:1365–1378.

Nel, A., Xia, T., Madler, L. and Li, N. 2006. Toxic potential of materials at the nano level. Science. 311: 622–627.

Nollet, L., Van, J. D., Der, K., Lis, M. and Lensing, P. S. 2007. The effect of replacing inorganic with organic trace minerals in broiler diets on productive performance and mineral excretion. Journal of Applied Poultry Research. 16(4): 592-597.

NRC. 1994. Nutrient Requirements of Poultry. 9th ed. National Academic Press, Washington, DC, USA.

Ognik, K., Stępniowska, A., Cholewinska, E. and Kozlowski, K. 2016. The effect of administration of copper nanoparticles to chickens in drinking water on estimated intestinal absorption of iron, zinc, and calcium. Poultry Science. 95(9): 2045–2051.

Ognik., K., Cholewinska, E., Stępniowska, A., Drazbo, A., Kozlowski, K. and Jankowski, J. 2019. The effect of administration of copper nanoparticles in drinking water on redox reactions in the liver and breast muscle of broiler chickens. Annals of Animal Science. 19(3): 663-677.

Ognik, K., Sembratowicz, I., Cholewinska, E., Jankowski, J., Kozlowski, K., Juskiewicz, J. and Zdunczyk, Z. 2017. The effect of administration of copper nanoparticles to chickens in their drinking water on the immune and antioxidant status of the blood. Animal Science Journal. 89(3): 579-588.

Pang, Y.F. and Applegate, T.J. 2006. Effects of copper source and concentration on in vitro phytate phosphorus hydrolysis by phytase. Journal of Agriculture and Food Chemistry. 54(5):1792–1796.

Patra, A. and Lalhriatpuii, M. 2019. Progress and prospect of essential mineral nanoparticles in poultry nutrition and feeding—a Review. Biological Trace Element Research. 197(1): 233-253.

Peters, R. J. B., Bouwmeester, H., Weigel, S. and Aschberge, R. K. 2016. Nanomaterials for products and application in agriculture, feed and food. Trends in Food Science and Technology. 54:155–164.

Petrarca, C., Clemente, E., Amato, V., Pedata, P., Sabbioni, E., Bernardini, G., Iavicoli, I., Cortese, S., Niu, Q., Otsuki, T. and Paganelli, R. 2015. Engineered metal based nanoparticles and innate immunity. Clinical and Molecular Allergy. 13(1): 1-12.

Pineda, L., Sawosz, E., Vadalasetty, K. P. and Chwalibog, A. 2013. Effect of copper nanoparticles on metabolic rate and development of chicken embryos. Animal Feed Science and Technology. 186(1-2): 125–129.

Prescott, J. F. and Baggo, J. D. 1993. Antimicrobial Therapy in Veterinary Medicine, 2nd ed., Iowa State University Press, 564–565.

Raje, K., Ojha, S. and Chaudhary, S.K. 2018. Impact of supplementation of mineral nano particles on growth performance and health status of animals: a review. Journal of Entomology and Zoology Study. (6): 690-4.

Rakhmetova, A.A., Alekseeva, T.P., Bogoslovskaya, O.A., Leipunskii, I.O., Ol’khovskaya, I.P., Zhigach, A.N. and Glushchenko, N.N. 2010. Wound-healing properties of copper nanoparticles as a function of physicochemical parameters. Nanotechnology. 5(3): 271–276.

Ramesh, J. 2014. Effect of nanomineral supplementation in TANUVAS smart mineral mixture on the performance of lambs. Doctoral Dissertation, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, India.

Refaie, A.M., Ghazal, M.N., Easa, F.M., Barakat, S.A., Ge, Y. and Wh, E. 2015. Nano-copper as a new growth promoter in the diet of growing New Zealand white rabbits. Egyptian Journal of Rabbit Science. 25(1): 39–57.

Rosi, N.L and Mirkin, C.A. 2005. Nanostructures in bio diagnostics. Chemistry Review. 105(4): 1547–1562.

Sadauskas, E., Wallin, H., Stoltenberg, M., Vogel, U., Doering, P. and Larsen, A. 2007. Kupfer cells are central in the removal of nanoparticles from the organism. Particle and Fibre Toxicology. 4(1): 1-7.

Samanta, B., Biswas, A. and Ghosh, P.R. 2011. Effects of dietary copper supplementation on production performance and plasma biochemical parameters in broiler chickens. British Poultry Science. 52(2): 573–577

Sawosz, E., Lukasiewicz, M., Lozicki, A., Sosnowska, M., Jaworski, S., Niemiec, J. and Chwalibog, A. 2018. Effect of copper nanoparticles on the mineral content of tissues and droppings, and growth of chickens. Archives of Animal Nutrition. 72(5): 396-406.

Scott, A., Prasad, K., Andre, V. C. and Sawosz, E. 2018. Copper nanoparticles as an alternative feed additive in poultry diet: a review. Nanotechnology Review. 7(1): 69–93.

Scott, A., Vadalasetty, K.P., Lukasiewicz, S. M., Vadalasetty, R.K.P., Jaworski, S. and Chwalibog, A. 2016. Effect of copper nanoparticles and copper sulphate on metabolic rate and development of broiler embryos. Animal Feed Science and Technology. 220: 151–158.

Scott, A., Vadalasetty, K.P., Lukasiewicz, M., Jaworski, S., Wierzbicki, M. and Chwalibog, A. 2017. Effect of different level of copper nanoparti¬cles and copper sulphate on performance, metabolism and blood biochemical profile in broiler chicken. Journal of Animal Physiology and Animal Nutrition. 102(1):1–10.

Shankar, S. and Rhim J.W. 2014. Effect of copper salts and reducing agents on characteristics and antimicrobial activity of copper nanoparticles. Materials Letter. 132: 307–311.

Shannahan, J.H. and Brown, J.M. 2014. Engineered nanomaterial exposure and the risk of allergic disease. Current Opinion in Allergy and Clinical Immunology. 14(2): 95–99.

Sharif, M., Rahman, M.A.U., Ahmed, B., Abbas, R.Z. and Hassan, F.U. 2020. Copper nanoparticles as growth promoter, antioxidant and anti-bacterial agents in poultry nutrition: prospects and future implications. Biological Trace Element Research. 199(10): 3825-3836.

Sharma, M.C., Joshi, C., Pathak, N.N. and Kaur, H. 2005. Copper status and enzyme, hormone, vitamin and immune function in heifers. Research in Veterinary Science. 79(2): 113–123.

Kwon史,M,临睡时,彭,Z,, a,,H. 2012. Effects of surface chemistry on the generation of reactive oxygen species by copper nanoparticles. ACS Nano. 6(3): 2157–2164.

Skrivan, M., Skrivanova, V. and Marounek, M. 2005. Effects of dietary zinc, iron, and copper in layer feed on distribution of these elements in eggs, liver, excreta, soil, and herbage. Poultry Science. 84(10):1570–1575.

Suttle, N. F. 2010. Mineral Nutrition of Livestock, 4th Edition, Printed and bound in the UK by the MPG Books Group. ISBN-13: 978 1 84593 472 9.

Tamilvanan, A., Balamurugan, K., Ponappa, K. and Kumar, B.M. 2014. Copper nanoparticles: synthetic strategies, properties and multifunctional application. International Journal of Nano-Science. 13(02):143.

Usman, M., Zowalaty, E.L., Shameli, M., Zainuddin, K., Salama, N. and Ibrahim, M. N.A. 2013. Synthesis, characterization, and antimicrobial properties of copper nanoparticles. International Journal of Nano-medicine, 8: 4467.

Wang, C., Wang, M.Q., Ye, S.S., Tao, W.J. and Du, Y.J. 2011. Effects of copper-loaded chitosan nanoparticles on growth and immunity in broilers. Poultry Science. 90(10): 2223-2228.

Wang, H., Zhang, C., Mi, Y. and Kidd, M. 2014. Copper and lysine amino acid density responses in commercial broilers. Journal of Applied Poultry Research. 23(3): 470 - 477.

Wang, Z.L. 2000. Characterizing the structure and properties of individual wire-like nanoentities. Advances in Materials. 12(17): 1295–1298.

Wu, X. Z., Zhang, T. T., Gu, J. G and Liu, Z. 2015. Copper bioavailability, blood parameters, and nutrient balance in mink. Journal of Animal Science. 93(1): 176-184.

Xia, X., Xie, C., Cai, S., Yang, Z. and Yang, X. 2006. Corrosion characteristics of copper microparticles and copper nanoparticles in distilled water. Corrosion Science. 48(12): 3924–3932.

Xin, F. 2015. Oxidative stress induced by Cuo nanoparticles (CuO NPs) to Human Hepato carcinoma (HepG2) Cells. Journal of Cancer Therapy. 6(10):889–895

Yang, Z., Guo, Z., Qiu, C., Li, Y., Feng, X., Liu, Y., Zhang, Y., Pang, P., Wang, P., Zhou, Q. and Han, L. 2016. Preliminary analysis showed country-specific gut resistome based on 1267 feces samples. Gene. 581(2): 178-182.

Yang, Z., Qi, X.M., Yang, H.M., Dai, H., Xu, C.X. and Wang, Z.Y. 2018. Effects of dietary copper on growth performance, slaughter performance and nutrient content of fecal in growing goslings from 28 to 70 days of age. Brazilian Journal of Poultry Science. 20(1): 45-52.

Yausheva, E.V. 2021. Increasing efficiency in the poultry meat production when using iron and copper nanoparticles in nutrition. In IOP Conference Series: Earth and Environmental Science. 624(1):012046.

Zaboli, K., Aliarabi, H., Bahari, A.A. and Abbas, A.K.R. 2013. Role of dietary nano-zinc oxide on growth performance and blood levels of mineral: A study on in Iranian Angora (Markhoz) goat kids. Journal of Pharmacology and Health Science. 2: 19–26.

Zhang, F., Zheng, W., Guo, R. and Yao, W. 2017. Effect of dietary copper level on the gut microbiota and its correlation with serum inflammatory cytokines in Sprague-Dawley rats. Journal of Microbiology. 55(9): 694–702.

Zhou, W., Komegay, E.T., Lindemann, M.D., Swinkels, J.W., Welton, M.K. and Wong, E.A. 1994. Stimulation of growth by intravenous injection of copper in weanling pigs. Journal of Animal Science.72: 2395-2403.






How to Cite

Noor, A., T M, P., B N, S., & A. Mostamand. (2023). Nano Copper in Poultry Nutrition: Potential Effect and Future Prospect - A Review: .Indian Journal of Animal Nutrition,39(4). Retrieved from //